gene 509 words KG: JAM2 2026-03-21
kind:genesection:genesstate:published
Contents

JAM2 - Junctional Adhesion Molecule 2

🧬 Gene Info
Gene SymbolJAM2
Full NameJunctional Adhesion Molecule 2
AliasesPage for JAM2
FunctionJAM2 mediates homophilic (JAM2-JAM2) and heterophilic (JAM2-JAM3) interactions at cell junctions
Primary Expressionbrain endothelial cells forming the blood-brain barrier, with lower expression in neurons (particularly in the [hippocampus](/bra
Ensembl IDENSG00000176182
GeneCardsJAM2
Human Protein AtlasJAM2
Associated DiseasesALS, Aging, Ataxia, Ms, Parkinson
InteractionsPDGFB, PDGFRB, MYORG, SLC20A2, XPR1, CMPK2
KG Connections44 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44
Piezoelectric Nanochannel BBB Disruption
Score: 0.41
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
PDGFB — Platelet Derived Growth Factor Subunit B
gene · KG edge: associated_with
OCLN — Occludin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

JAM2 associated_with PDGFRB
JAM2 associated_with PDGFB
JAM2 associated_with OCLN
JAM2 associated_with JUN
JAM2 associated_with Primary Familial Brain Calcification
JAM2 interacts_with PDGFB
JAM2 associated_with Rb
JAM2 interacts_with PDGFRB
JAM2 binds_to PDGFRB
JAM2 causes Primary Familial Brain Calcification