concept

CMPK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CMPK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

80Connections

0Hypotheses

0Analyses

50Outgoing

15Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CMPK2
Key Genes/Proteins	GENES, MITOCHONDRIAL DYSFUNCTION
Related Diseases	Primary Familial Brain Calcification, Ischemic Stroke, Parkinson, Aging, ALS
Related Pathways	NLRP3 Inflammasome

Pathway Diagram

graph TD
    CMPK2["CMPK2"]
    CMPK2 -->|"activates"| Als["Als"]
    CMPK2 -->|"activates"| SNAP23["SNAP23"]
    CMPK2 -->|"activates"| ZBP1["ZBP1"]
    CMPK2 -->|"activates"| RFK["RFK"]
    CMPK2 -->|"activates"| BAX["BAX"]
    CMPK2 -->|"activates"| APOPTOSIS["APOPTOSIS"]
    CMPK2 -->|"activates"| CHAC1["CHAC1"]
    CMPK2 -->|"activates"| HERC5["HERC5"]
    ISG15["ISG15"] -->|"activates"| CMPK2

Outgoing (65)

Target	Relation	Type	Str
Primary Familial Brain Calcification	associated_with	disease	0.95
mtDNA Replication	regulates	process	0.95
Neuroinflammation	associated_with	process	0.95
Primary Familial Brain Calcification	causes	disease	0.95
Microglia	expressed_in	cell_type	0.90
Ischemic Stroke	contributes_to	disease	0.90
NLRP3 Inflammasome	activates	pathway	0.85
mitochondrial dysfunction	contributes_to	process	0.80
Parkinson	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
GENES	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
JAM2	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
SLC20A2	associated_with	gene	0.60
PDGFB	associated_with	gene	0.60
JUN	associated_with	gene	0.60
AND	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
MYORG	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
Pdgf	associated_with	protein	0.60
Rb	associated_with	protein	0.60
SNAP23	activates	gene	0.60
ZBP1	activates	gene	0.60
RFK	activates	gene	0.60
BAX	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CHAC1	activates	gene	0.60
HERC5	activates	gene	0.60
Caspase	activates	protein	0.60
JAM2	interacts_with	gene	0.60
MYORG	interacts_with	gene	0.60
PDGFB	interacts_with	gene	0.60
PDGFRB	interacts_with	gene	0.60
SLC20A2	interacts_with	gene	0.60
XPR1	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
stroke	interacts_with	disease	0.60
NLRP3	regulates	gene	0.60
NLRP3	expressed_in	gene	0.60
STING	expressed_in	gene	0.60
STING	activates	gene	0.60
STING	regulates	gene	0.60
neuroinflammation	regulates	disease	0.60

Incoming (15)

Source	Relation	Type	Str
PDGFRB	associated_with	gene	0.60
PDGFB	associated_with	gene	0.60
JUN	associated_with	gene	0.60
SLC20A2	associated_with	gene	0.60
MYORG	associated_with	gene	0.60
XPR1	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
JAM2	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
ISG15	activates	gene	0.60
AR	expressed_in	gene	0.60
AR	activates	gene	0.60
AR	regulates	gene	0.60
ASC	expressed_in	gene	0.60
CASP1	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found