gene 537 words KG: PDGFB 2026-03-21
kind:genesection:genesstate:published
Contents

PDGFB — Platelet Derived Growth Factor Subunit B

🧬 Gene Info
Gene SymbolPDGFB
Full NamePlatelet Derived Growth Factor Subunit B
Chromosome22q13
FunctionPDGFB encodes the B chain of platelet-derived growth factor, which can form homodimers (PDGF-BB) or heterodimers (PDGF-AB) with the A chain.
PathwaysInflammasome
UniProt ID[P01127](https://www.uniprot.org/uniprot/P01127)
Ensembl IDENSG00000127314
OMIM190040
GeneCardsPDGFB
Human Protein AtlasPDGFB
Associated DiseasesALS, Aging, Basal Ganglia Calcifications, Fahr_disease, Ms
InteractionsMERTK, TREM2, PDGFRB, PDGF, Il-1, App
KG Connections90 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Retinal Vascular Microcirculation Rescue
Score: 0.54
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.41

Related Analyses (4)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
JUN Gene
gene · KG edge: associated_with
JAM2 - Junctional Adhesion Molecule 2
gene · KG edge: associated_with
CSF2 — Colony Stimulating Factor 2 (GM-CSF)
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

PDGFB causes Fahr_disease
PDGFB associated_with PDGFRB
PDGFB regulates PDGFRB
PDGFB expressed_in BLM
PDGFB expressed_in Basal Ganglia
PDGFB associated_with JAM2
PDGFB associated_with JUN
PDGFB associated_with Primary Familial Brain Calcification
PDGFB risk_factor_for Fahr's Disease
PDGFB causes Basal Ganglia Calcifications