| Gene Symbol | KAT2A |
| Full Name | Lysine Acetyltransferase 2A |
| Chromosome | 17q21.2 |
| Protein Type | Transferase |
| Function | encodes a histone acetyltransferase that catalyzes the acetylation of histone H3 at lysines 9, 14, 18, and 36 (H3K9ac, H3K14ac, H3K18ac, H3K36ac). |
| Amino Acids | 837 aa |
| Pathways | Chaperone, Invasion, Metastasis, Tgf-Β, Tgf-Β Signaling |
| UniProt ID | [Q92830](https://www.uniprot.org/uniprot/Q92830) |
| Ensembl ID | ENSG00000108773 |
| GeneCards | KAT2A |
| Human Protein Atlas | KAT2A |
| HAT domain | Catalytic acetyltransferase domain that transfers acetyl groups from acetyl-CoA to histone lysine residues |
| Bromodomain | Chromatin reader module that recognizes pre-existing acetylated histones, particularly H4K16ac, enabling positive-feedback acetylation spreading |
| ADA2-interaction domain | Mediates incorporation into the SAGA (Spt-Ada-Gcn5-Acetyltransferase) and ATAC (Ada Two A-Containing) multi-subunit complexes |
| ATAC complex | Contains KAT2A and the histone acetyltransferase ATAC2. ATAC specifically acetylates H3K14 and H4K5/12 at enhancers and is involved in mitotic chromosome condensation. |
| Associated Diseases | Parkinson, Tumor |
| Known Drugs/Compounds | rapamycin |
| Interactions | MYC, MARK4, HSPA8, CALCOCO2, HSP70, LC3 |
| KG Connections | 211 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |