gene 680 words KG: CREBBP 2026-03-22
kind:genesection:genesstate:published
Contents

CREBBP Gene

🧬 Gene Info
Gene SymbolCREBBP
Full NameCREB Binding Protein
Chromosome16p13.3
Protein TypeTranscription Factor
Functionis a transcriptional coactivator that acetylates histones and transcription factors
Primary Expressionmost neuronal subtypes including pyramidal cells, interneurons - Glia: Present in astrocytes and [microglia](/entities/mic
Molecular Weight265 kDa
PathwaysNF-κB
UniProt IDQ92793 (CREBBP)
NCBI Gene ID1387
Ensembl IDENSG00000105383
OMIM600140
GeneCardsCREBBP
Human Protein AtlasCREBBP
Associated DiseasesALS, Cancer, Parkinson, Tumor
Known Drugs/Compoundsrapamycin
InteractionsIL6ST, CREB1, KMT2D, BCL2, LRP1, CALCOCO2
KG Connections491 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (14)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61

Related Analyses (5)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: regulates
AXIN2 Gene
gene · KG edge: regulates
AXIN1 Gene
gene · KG edge: regulates
ATF3 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CREBBP associated_with NBR1
CREBBP associated_with GAPDH
CREBBP associated_with HSP70
CREBBP associated_with NDP52
CREBBP associated_with VAMP8
CREBBP associated_with EP300
CREBBP associated_with MTOR
CREBBP associated_with PIK3C3
CREBBP associated_with LAMP2A
CREBBP associated_with KAT2A