gene 680 words KG: CREBBP
Contents

CREBBP Gene

🧬 Gene Info
Gene SymbolCREBBP
Full NameCREB Binding Protein
Chromosome16p13.3
Protein TypeTranscription Factor
Functionis a transcriptional coactivator that acetylates histones and transcription factors
Primary Expressionmost neuronal subtypes including pyramidal cells, interneurons - Glia: Present in astrocytes and [microglia](/entities/mic
Molecular Weight265 kDa
PathwaysNF-κB
UniProt IDQ92793 (CREBBP)
NCBI Gene ID1387
Ensembl IDENSG00000105383
OMIM600140
GeneCardsCREBBP
Human Protein AtlasCREBBP
Associated DiseasesALS, Cancer, Parkinson, Tumor
Known Drugs/Compoundsrapamycin
InteractionsACAT1, AMPK, APOPTOSIS, ATG, BCL2, CALCOCO2
SciDEX HypothesesSynaptic Chromatin Compartment Rejuvenation
KG Connections485 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.89
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (5)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

KAT2B associated_with CREBBP
KAT8 associated_with CREBBP
OPTN associated_with CREBBP
ULK1 associated_with CREBBP
CALCOCO2 associated_with CREBBP
HSPA8 associated_with CREBBP
STX17 associated_with CREBBP
SQSTM1 associated_with CREBBP
RB1CC1 associated_with CREBBP
SIRT1 associated_with CREBBP

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