gene 1,337 words KG: KCNN3 2026-03-27
kind:genesection:genesstate:published
Contents

KCNN3 — Potassium Calcium-Activated Channel Subfamily N Member 3

🧬 Gene Info
Gene SymbolKCNN3
Full NamePotassium Calcium-Activated Channel Subfamily N Member 3
AliasesSmall Conductance Calcium-Activated Potassium Channel 3
Chromosome4q22.1
Protein FamilySK/IK calcium-activated potassium channel family
Protein TypeChannel
Functionis a member of the calcium-activated potassium channel family that plays a critical role in regulating neuronal excitability and synaptic transmission.
Molecular Weight70 kDa
Amino Acids731 aa
Exons10
UniProt ID[Q9GZP1](https://www.uniprot.org/uniprot/Q9GZP1)
Ensembl IDENSG00000163631
OMIM609923
GeneCardsKCNN3
Human Protein AtlasKCNN3
Associated DiseasesAlzheimer, Inflammation, Ms, Parkinson
Known Drugs/CompoundsTriarylmethane-34
InteractionsMAPT, SNCA
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.49
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Alzheimer Indonesia
institution · KG edge: associated_with
PRKN — Parkin RBR E3 Ubiquitin Protein Ligase
gene · KG edge: associated_with
MAPT (Microtubule-Associated Protein Tau) Gene
gene · KG edge: interacts_with
GRIN2B — NMDA Receptor Subunit 2B
gene · KG edge: associated_with
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

KCNN3 associated_with GRIN2B
KCNN3 associated_with CAV1
KCNN3 associated_with GAIN
KCNN3 associated_with CACNA1C
KCNN3 associated_with PRKN
KCNN3 interacts_with MAPT
KCNN3 associated_with Pyramidal
KCNN3 associated_with Nmda Receptor
KCNN3 associated_with Alzheimer
KCNN3 associated_with Ms