gene 931 words KG: KDM1A
Contents

KDM1A (Lysine Specific Demethylase 1A)

🧬 Gene Info
Gene SymbolKDM1A
Full NameLysine Specific Demethylase 1A
AliasesLysine Specific Demethylase 1A (LSD1
Chromosome1p36.22
Protein FamilyLSD1 family (Flavin-dependent amine oxidase)
Functionis a crucial epigenetic regulator that catalyzes the removal of methyl groups from histone lysine residues.
PathwaysFerroptosis, bone metabolism, epigenetic regulation
UniProt IDO60341
NCBI Gene ID23028
Ensembl IDENSG00000136867
OMIM607042
GeneCardsKDM1A
Human Protein AtlasKDM1A
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Neurodevelopmental Disorders
InteractionsSLC7A11, HDAC2, EP300, KDM6A, FERROPTOSIS
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (22)

KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.38
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Senescent Cell Mitochondrial DNA Release
Score: 0.54

Related Analyses (2)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
SLC7A11 Gene - xCT Cystine/Glutamate Antiporter
gene · KG edge: activates
HDAC2 Gene
gene · KG edge: inhibits
EP300 Gene
gene · KG edge: inhibits
EHMT2 — Euchromatic Histone Lysine Methyltransferase 2
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

KDM1A activates SLC7A11
KDM1A inhibits HDAC2
KDM1A therapeutic_target DNMT1
KDM1A therapeutic_target EHMT2
KDM1A inhibits EP300
KDM1A regulates bone metabolism
KDM1A activates KDM6A
KDM1A regulates CANCER
KDM1A activates FERROPTOSIS
KDM1A regulates Cancer