gene 841 words KG: MBD2 2026-03-24
kind:genesection:genesstate:published
Contents

MBD2 Gene - Methyl-CpG Binding Domain Protein 2

🧬 Gene Info
Gene SymbolMBD2
Full NameMethyl-CpG Binding Domain Protein 2
AliasesPage for MBD2 Gene, Page for MBD2 Protein
Chromosome18q21.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe brain with particularly high levels in:
Molecular Weight46 kDa
Amino Acids80 aa
UniProt IDQ9UBT4
NCBI Gene ID8932
Ensembl IDENSG00000134046
OMIM605078
GeneCardsMBD2
Human Protein AtlasMBD2
Associated DiseasesMs
InteractionsABCB1, KMT2A
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.59
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.88
CYP46A1 Overexpression Gene Therapy
Score: 0.86
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78

Related Analyses (11)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: expressed_in
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: expressed_in
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: expressed_in
MAPK14 — Mitogen-Activated Protein Kinase 14 (p38α)
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

MBD2 activates ABCB1
MBD2 activates KMT2A
MBD2 expressed_in AKT
MBD2 expressed_in MAPK14
MBD2 regulates Carcinoma
MBD2 associated_with Ms
MBD2 activates Tumor
MBD2 expressed_in ERK1/2
MBD2 expressed_in MAPK
MBD2 expressed_in Dna Methylation

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