gene 1,437 words KG: MEF2D 2026-03-26
kind:genesection:genesstate:published
Contents

MEF2D — Myocyte Enhancer Factor 2D

🧬 Gene Info
Gene SymbolMEF2D
Full NameMyocyte Enhancer Factor 2D
AliasesPage for MEF2D Protein
Chromosome5q14.1
Protein TypeTranscription Factor
FunctionNeurotransmitter-related genes
Primary ExpressionCortex, Hippocampus, Striatum, Cerebellum, Substantia Nigra
Molecular Weight55.4 kDa
Amino Acids507 aa
Exons13
PathwaysMAPK
UniProt IDQ01484
NCBI Gene ID4209
Ensembl IDENSG00000105509
OMIM600663
GeneCardsMEF2D
Human Protein AtlasMEF2D
Associated DiseasesParkinson's Disease, Huntington's Disease, Alzheimer's Disease
InteractionsMMP9, APOPTOSIS, EP300
KG Connections19 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (9)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
MMP9 Gene
gene · KG edge: inhibits
HDAC9 Gene
gene · KG edge: associated_with
HDAC7 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

MEF2D associated_with HDAC9
MEF2D inhibits MMP9
MEF2D associated_with STAT6
MEF2D activates APOPTOSIS
MEF2D therapeutic_target Aging
MEF2D therapeutic_target Cardiovascular
MEF2D activates Apoptosis
MEF2D associated_with GENE MUTATIONS
MEF2D activates Leukemia
MEF2D associated_with Epigenetic