gene 1,563 words KG: HDAC9 2026-03-26
kind:genesection:genesstate:published
Contents

HDAC9 Gene

🧬 Gene Info
Gene SymbolHDAC9
Full NameHistone Deacetylase 9
Chromosome7p21.1
Functionencodes a class IIa histone deacetylase that plays crucial roles in epigenetic regulation, transcriptional control, and cellular signaling in the brain.
Primary ExpressionBrain, heart, skeletal muscle
Molecular Weight110 kDa
UniProt IDQ9UKV0
NCBI Gene ID9734
Ensembl IDENSG00000048828
OMIM606365
GeneCardsHDAC9
Human Protein AtlasHDAC9
Associated DiseasesAls, Coronary Artery Disease, Inflammation, Stroke
InteractionsNRF2, KDR, POU5F1, INFLAMMATION, NANOG, HDAC5
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58

Related Analyses (7)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
MMP12 - Matrix Metallopeptidase 12
gene · KG edge: associated_with
MEF2D — Myocyte Enhancer Factor 2D
gene · KG edge: associated_with
ATM Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

HDAC9 associated_with ALDH2
HDAC9 associated_with APOE
HDAC9 co_expressed_with NRF2
HDAC9 activates NRF2
HDAC9 activates KDR
HDAC9 activates POU5F1
HDAC9 activates INFLAMMATION
HDAC9 activates Stroke
HDAC9 therapeutic_target Ms
HDAC9 activates Atherosclerosis