Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about aph1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | APH1A, APH1B |
| Full Name | APH1A |
| Aliases | APH1, aph1 |
| Protein Family | APH-1 family (γ-secretase complex) |
| Protein Type | Gene |
| Function | Complex Formation Initiation: APH-1 binds to presenilin in the ER, initiating complex assembly |
| Primary Expression | Endoplasmic reticulum, Golgi apparatus, plasma membrane |
| Molecular Weight | 35 kDa |
| Amino Acids | 346 aa |
| UniProt ID | Q9WVM4 |
| Associated Diseases | Alzheimer's Disease, Frontotemporal Dementia |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
APH1["APH1"]
APH1 -->|"activates"| Alzheimer["Alzheimer"]
APH1 -->|"activates"| Als["Als"]
APH1 -->|"expressed in"| Cancer["Cancer"]
APH1 -->|"expressed in"| Leukemia["Leukemia"]
APH1 -->|"contributes to"| STAT3["STAT3"]
APH1 -->|"expressed in"| NCSTN["NCSTN"]
APH1 -->|"expressed in"| CANCER["CANCER"]
APP["APP"] -->|"contributes to"| APH1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| APH1
STAT3 -->|"contributes to"| APH1
NEURON["NEURON"] -->|"activates"| APH1
ALZHEIMER["ALZHEIMER"] -->|"activates"| APH1
APOPTOSIS["APOPTOSIS"] -->|"expressed in"| APH1
ADAM17["ADAM17"] -->|"expressed in"| APH1
NOTCH1["NOTCH1"] -->|"expressed in"| APH1| Target | Relation | Type | Str |
|---|---|---|---|
| Gamma-Secretase Complex | interacts_with | protein | 0.90 |
| Alzheimer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Leukemia | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| STAT3 | contributes_to | gene | 0.60 |
| NCSTN | expressed_in | gene | 0.60 |
| MYC | expressed_in | gene | 0.60 |
| NCT | activates | gene | 0.60 |
| PSEN | activates | gene | 0.60 |
| PSEN | interacts_with | gene | 0.60 |
| PSEN1 | interacts_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| STAT3 | associated_with | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| Notch | expressed_in | pathway | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||