gene 727 words KG: NPAS2 2026-03-22
kind:genesection:genesstate:published
Contents

NPAS2 Gene

🧬 Gene Info
Gene SymbolNPAS2
Full NameNeuronal PAS Domain Protein 2
Chromosome2q22.1
FunctionThe NPAS2 gene encodes Neuronal PAS Domain Protein 2, a transcription factor that serves as a core component of the mammalian circadian clock.
Molecular Weight87 kDa
PathwaysCBFs
UniProt IDQ8BZD0
NCBI Gene ID10327
Ensembl IDENSG00000107077
OMIM605504
GeneCardsNPAS2
Human Protein AtlasNPAS2
Associated DiseasesFreezing Tolerance
InteractionsPER1, PER2, BMAL1, MTNR1A, MTNR1B
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Purinergic Signaling Polarization Control
Score: 0.55
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: expressed_in
PER1 Gene
gene · KG edge: associated_with
NR1D1 — Nuclear Receptor Subfamily 1 Group D Member 1 (
gene · KG edge: expressed_in
CRY2 Gene
gene · KG edge: associated_with
CRY1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NPAS2 associated_with CRY2
NPAS2 associated_with PER2
NPAS2 associated_with CLOCK
NPAS2 associated_with BMAL1
NPAS2 interacts_with HOS1
NPAS2 participates_in CBFs
NPAS2 associated_with Freezing Tolerance
NPAS2 associated_with MTNR1A
NPAS2 expressed_in PER3
NPAS2 associated_with PER1