gene 842 words KG: GALC 2026-03-24
kind:genesection:genesstate:published
Contents

GALC Gene

🧬 Gene Info
Gene SymbolGALC
Full NameGalactocerebrosidase
Chromosome14q31.3 (Chr14: 87,934,475-88,013,430)
FunctionGALC encodes galactocerebrosidase, a lysosomal hydrolase that catalyzes the hydrolysis of galactocerebroside, a major lipid component of myelin.
Primary Expressionbrain white matter, peripheral nerves
Molecular Weight80 kDa
PathwaysTgf-Β
UniProt IDP54803
NCBI Gene ID2581
Ensembl IDENSG00000135837
OMIM245000
GeneCardsGALC
Human Protein AtlasGALC
Age of OnsetForm
0-6 monthsInfantile
Associated DiseasesMs
InteractionsRAC1, PSAP, GPR37, SMAD4, CTSD, GLA
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Packard Center for ALS Research
institution · KG edge: activates
PLP1 Gene
gene · KG edge: causes
GPR37 Gene
gene · KG edge: activates
CTSD — Cathepsin D
gene · KG edge: interacts_with
ARSA Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GALC activates RAC1
GALC interacts_with PSAP
GALC activates GPR37
GALC activates SMAD4
GALC interacts_with CTSD
GALC contributes_to PSAP
GALC causes PLP1
GALC inhibits GLA
GALC inhibits LRRK2
GALC activates CANCER