gene 2,857 words KG: SLC17A6 2026-03-27
kind:genesection:genestopic:glutamatetopic:synapsetopic:alzheimerstopic:parkinsonsstate:published
Contents

SLC17A6 Gene

🧬 Gene Info
Gene SymbolSLC17A6
Full NameSolute Carrier Family 17 Member 6
AliasesVGLUT2
Chromosome11q14.1
Protein TypeTransporter
Functionis a critical vesicular glutamate transporter responsible for packaging glutamate into synaptic vesicles at excitatory synapses.
Primary Expressionspecific neuronal populations:
Molecular Weight64 kDa
Amino Acids582 aa
Exons16
PathwaysEpigenetic, Synaptic Plasticity, Synaptic Vesicle, autophagy pathway
UniProt ID[Q9P2U7](https://www.uniprot.org/uniprot/Q9P2U7)
Ensembl IDENSG00000164690
GeneCardsSLC17A6
Human Protein AtlasSLC17A6
Associated DiseasesALS, Cancer, Tumor
InteractionsVGLUT1, TAU, VGLUT2, SNAP25, GRIA2, PVALB
KG Connections176 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.37

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Sex differences in CB1R-mediated cannabinoid analgesia in ne
validation · proposed · Score: 0.90
Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with
Dementia Australia
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: expressed_in
GRIN2A Gene
gene · KG edge: biomarker_for

Knowledge Graph (12 edges)

SLC17A6 associated_with VGLUT2
SLC17A6 biomarker_for SLC12A5
SLC17A6 biomarker_for SYN2
SLC17A6 biomarker_for GAD1
SLC17A6 biomarker_for SYP
SLC17A6 biomarker_for SLC32A1
SLC17A6 biomarker_for GRIN2A
SLC17A6 biomarker_for PVALB
SLC17A6 biomarker_for SNAP25
SLC17A6 associated_with NPY