gene 1,890 words KG: GRIA2 2026-03-27
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

GRIA2 Gene

🧬 Gene Info
Gene SymbolGRIA2
Full NameGlutamate Ionotropic Receptor AMPA Type Subunit 2
Chromosome4q32.1
Functioncontrol and synaptic plasticity
Molecular Weight98 kDa
Amino Acids883 aa
PathwaysAutophagy, Mitophagy, autophagy pathway, mitophagy, ubiquitin-proteasome
UniProt IDP42263
NCBI Gene ID2892
Ensembl IDENSG00000120251
OMIM138247
GeneCardsGRIA2
Human Protein AtlasGRIA2
Protein NameGlutamate receptor 2 (GluA2)
Protein ClassIonotropic glutamate receptor (AMPA type)
Associated DiseasesALS, Cancer, Tumor
InteractionsPRKN, PARKIN, XBP1, COX4I1, HSPD1, PTEN
KG Connections105 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
APOE Isoform Conversion Therapy
Score: 0.44

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Stress-induced depression model sleep architecture analysis
validation · proposed · Score: 0.90

See Also (10)

HSP60 (Heat Shock Protein 60)
protein · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
HSPD1 Gene - Heat Shock Protein Family D Member 1
gene · KG edge: activates
FOXO3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

GRIA2 activates HSP60
GRIA2 activates OPTINEURIN
GRIA2 activates TOMM20
GRIA2 activates PRKN
GRIA2 activates PARKIN
GRIA2 activates XBP1
GRIA2 activates COX4I1
GRIA2 activates HSPD1
GRIA2 activates PTEN
GRIA2 activates PINK1