| Gene Symbol | SORLA |
| Pathways | Exocytosis, Immune Response, Lysosomal Degradation, Neurogenesis, Amyloid |
| GeneCards | SORLA |
| Human Protein Atlas | SORLA |
| APP trafficking | SORLA binds to APP in the Golgi and prevents its transport to the amyloidogenic endosomal pathway where beta-secretase cleavage occurs |
| Retromer function | SORLA interacts with the retromer complex (VPS26/VPS29/VPS35) to facilitate retrograde transport from endosomes to the trans-Golgi network |
| Aβ clearance | SORLA regulates the cellular clearance of amyloid-beta (Aβ) through endosomal and lysosomal pathways |
| Lipoprotein receptor | Binds LDL and VLDL particles, playing a role in lipid metabolism |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Bipolar, Coronary Artery Disease |
| Interactions | APP, PKC, Rb, AND, AMYLOID, Raf |
| KG Connections | 105 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |