gene

arrb2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arrb2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

25Outgoing

5Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ARRB2
Full Name	Arrestin Beta 2
Chromosome	17p13.1
Protein Type	Beta-arrestin (Scaffold Protein)
Function	is a member of the arrestin family of proteins that plays critical roles in regulating G protein-coupled receptor (GPCR) signaling, receptor internalization, and downstream signal transduction.
Molecular Weight	46 kDa
Amino Acids	409 aa
Pathways	MAPK, PI3K, NF-κB pathway, MAPK pathway
UniProt ID	P35610
NCBI Gene ID	410
GeneCards	ARRB2
Human Protein Atlas	ARRB2
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: arrb2 — AlphaFold P35610 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    N0["ARRB2"]
    N1["NLRP3"]
    N0 -->|"interacts with"| N1
    N2["Anti-Inflammatory Reactivity"]
    N0 -->|"modulates"| N2
    N3["DRD2"]
    N3 -->|"activates"| N0
    N4["NEUROINFLAMMATION"]
    N0 -->|"mediates"| N4
    N5["SAMD4"]
    N0 -->|"regulates"| N5
    N6["IL-4"]
    N6 -->|"regulates"| N0
    N7["IL4"]
    N7 -->|"regulates"| N0
    N8["SORLA"]
    N0 -->|"regulates"| N8
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 protein
    class N5 gene
    class N8 protein

Outgoing (25)

Target	Relation	Type	Str
NLRP3	interacts_with	protein	0.92
NLRP3	modulates	protein	0.91
Anti-Inflammatory Reactivity	modulates	process	0.90
SAMD4	regulates	gene	0.85
NEUROINFLAMMATION	mediates	process	0.85
SAMD4	interacts_with	protein	0.80
BIN1	causes	gene	0.70
CD2AP	causes	gene	0.70
CLCN1	causes	gene	0.70
neurodegeneration	causes	disease	0.70
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Hepatitis	activates	disease	0.65
SORLA	regulates	protein	0.60
NLRP3	activates	gene	0.60
ATP1A3	associated_with	gene	0.60
GLUD1	associated_with	gene	0.60
Innate Immunity	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Toll-Like Receptor	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
TLR	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
Macrophage	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
IL4	regulates	entity	0.85
IL-4	regulates	entity	0.85
TLR4	activates	gene	0.60
CASP1	activates	gene	0.60
IL1B	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

arrb2

Understanding Entity Pages

Wiki Pages (11)

ARRB2 — Arrestin Beta 2

OPRK1 — Kappa Opioid Receptor

GPR37 Gene

ARRB1 — Arrestin Beta 1

ARRB1 Protein — Arrestin Beta 1

GRK2 — G Protein-Coupled Receptor Kinase 2

ARRB2 Protein — Arrestin Beta 2

GRK6 Protein — G Protein-Coupled Receptor Kinase 6

IL4 Gene