gene 2,272 words KG: SPART 2026-03-28
kind:genesection:genesstate:published
Contents

SPART — Spartin

🧬 Gene Info
Gene SymbolSPART
Full NameSpartin
AliasesSPG20/Troyer syndrome
Chromosome4p16.3
Functionencodes a protein involved in lipid droplet metabolism, mitochondrial function, and endosomal trafficking.
Amino Acids628 aa
UniProt IDQ9UQ10
NCBI Gene ID55037
Ensembl IDENSG00000133104
OMIM607111
GeneCardsSPART
Human Protein AtlasSPART
SpastinHomology
ESCRT complexDirect binding
ATG proteinsIndirect
Associated Diseasesneurodegeneration
InteractionsAMPK
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Microbial Inflammasome Priming Prevention
Score: 0.58

Related Analyses (15)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

See Also (15)

p62 - Sequestosome 1 (SQSTM1)
protein · KG edge: associated_with
Lipophagy Pathway in Neurodegeneration
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: regulates
SQSTM1 — Sequestosome 1 (p62)
gene · KG edge: associated_with
PPARG — Peroxisome Proliferator-Activated Receptor Gamm
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SPART associated_with ATG14
SPART associated_with SREBP1
SPART regulates Diabetes
SPART regulates Cancer
SPART regulates Als
SPART regulates Nafld
SPART regulates Atherosclerosis
SPART regulates Fatty Liver
SPART regulates Neurodegeneration
SPART associated_with Lysosomal Degradation