gene 519 words KG: SRSF1
Contents

SRSF1

🧬 Gene Info
Gene SymbolSRSF1
Full NameSerine/Arginine Rich Splicing Factor 1
Chromosome17q22
FunctionSRSF1 (Serine/Arginine Rich Splicing Factor 1), also known as ASF/SF2, is a member of the serine/arginine (SR) family of splicing factors.
Molecular Weight28 kDa
Amino Acids248 aa
PathwaysMtor, Oxidative Stress
UniProt IDP07919
NCBI Gene ID6732
Ensembl IDENSG00000136450
OMIM603364
GeneCardsSRSF1
Human Protein AtlasSRSF1
Associated DiseasesALS
Known Drugs/CompoundsAntisense Oligonucleotides
InteractionsALS, AND, AUTOPHAGY, BECLIN1, C9ORF72, CANCER
KG Connections47 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
APOE-Dependent Autophagy Restoration
Score: 0.89
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Cross-Seeding Prevention Strategy
Score: 0.69
RNA Granule Nucleation Site Modulation
Score: 0.66
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
Genes
index · KG edge: activates
BECN1 Gene
gene · KG edge: interacts_with
MAP1LC3A Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

SRSF1 binds PIK3C3
SRSF1 interacts_with BECLIN1
SRSF1 interacts_with PIK3C3
SRSF1 inhibits LC3
SRSF1 associated_with Aberrant Splicing
Antisense Oligonucleotides targets SRSF1
SRPK1 phosphorylates SRSF1
SRSF1 phosphorylates SRSF2
HNRNPA1 co_expressed_with SRSF1
HNRNPA2B1 co_expressed_with SRSF1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.