gene 1,132 words KG: SUMO2
Contents

SUMO2 — Small Ubiquitin-Like Modifier 2

🧬 Gene Info
Gene SymbolSUMO2
Full NameSmall Ubiquitin-Like Modifier 2
AliasesPage for SUMO2 Protein
Chromosome17q25.1
Protein FamilySUMO family (ubiquitin-like)
Functionis a ubiquitin-like protein that plays critical roles in post-translational modification through SUMOylation.
Molecular Weight10.5 kDa
Amino Acids95 aa
PathwaysMitophagy, Oxidative Stress, oxidative stress response
UniProt ID[P61956](https://www.uniprot.org/uniprot/P61956)
Ensembl IDENSG00000193900
GeneCardsSUMO2
Human Protein AtlasSUMO2
E1 activating enzymeSAE1/UBA2 (SUMO-activating enzyme)
E2 conjugating enzymeUBC9 (SUMO-conjugating enzyme)
Associated DiseasesALS
InteractionsALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, DEMENTIA, DNA, MITOPHAGY
KG Connections35 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (12)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: activates
Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
MUL1 Gene
gene · KG edge: activates
NDP52 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

SUMO2 interacts_with RANBP2
RANBP2 interacts_with SUMO2
UBIQUITIN interacts_with SUMO2
SUMO2 activates PARKIN
SUMO2 activates PARL
SUMO2 activates MUL1
SUMO2 activates PINK1
SUMO2 regulates NDP52
TAU activates SUMO2
SUMO2 interacts_with UBIQUITIN

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.