gene 1,132 words KG: SUMO2 2026-03-24
kind:genesection:genesstate:published
Contents

SUMO2 — Small Ubiquitin-Like Modifier 2

🧬 Gene Info
Gene SymbolSUMO2
Full NameSmall Ubiquitin-Like Modifier 2
AliasesPage for SUMO2 Protein
Chromosome17q25.1
Protein FamilySUMO family (ubiquitin-like)
Functionis a ubiquitin-like protein that plays critical roles in post-translational modification through SUMOylation.
Molecular Weight10.5 kDa
Amino Acids95 aa
PathwaysMitophagy, Oxidative Stress, oxidative stress response
UniProt ID[P61956](https://www.uniprot.org/uniprot/P61956)
Ensembl IDENSG00000193900
GeneCardsSUMO2
Human Protein AtlasSUMO2
E1 activating enzymeSAE1/UBA2 (SUMO-activating enzyme)
E2 conjugating enzymeUBC9 (SUMO-conjugating enzyme)
Associated DiseasesALS
InteractionsRANBP2, PARKIN, PARL, MUL1, PINK1, UBIQUITIN
KG Connections38 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (12)

PARL Protein
protein · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Dementia Australia
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
SUMO1 — Small Ubiquitin-Like Modifier 1
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

SUMO2 interacts_with RANBP2
SUMO2 activates PARKIN
SUMO2 activates PARL
SUMO2 activates MUL1
SUMO2 activates PINK1
SUMO2 regulates NDP52
SUMO2 interacts_with UBIQUITIN
SUMO2 interacts_with SUMO1
SUMO2 interacts_with Sumo
SUMO2 interacts_with Ms