protein 513 words KG: PARL 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PARL Protein

🔬 Protein Info
Gene SymbolPARL
Full NamePARL
Chromosome3q27.1
Protein TypeProtein
FunctionOPA1 processing: Cleaves OPA1 (optic atrophy 1) to regulate mitochondrial fusion
Subcellular Localization** Inner mitochondrial membrane
Molecular Weight42 kDa
Amino Acids379 aa
PathwaysAutophagy
UniProt IDSearch UniProt
GeneCardsPARL
Human Protein AtlasPARL
Associated DiseasesAD, ALI, ALS, Alzheimer, Cardiac
InteractionsEIF2S1, CALCOCO2, MIRO1, PTEN, MFN1, PERK
KG Connections532 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Phase-Separated Organelle Targeting
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Autophagosome Maturation Checkpoint Control
Score: 0.49
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

PARL interacts_with EIF2S1
PARL interacts_with CALCOCO2
PARL interacts_with MIRO1
PARL interacts_with PTEN
PARL interacts_with MFN1
PARL interacts_with PERK
PARL interacts_with MAP1LC3B
PARL interacts_with BECN1
PARL interacts_with RHOT1
PARL interacts_with STING1