gene 532 words KG: SUMO1 2026-03-24
kind:genesection:genesstate:published
Contents

SUMO1 — Small Ubiquitin-Like Modifier 1

🧬 Gene Info
Gene SymbolSUMO1
Full NameSmall Ubiquitin-Like Modifier 1
AliasesPage for SUMO1 Protein
Chromosome2q33
FunctionSUMO1 encodes a small ubiquitin-like protein (~101 amino acids) that can be covalently attached to lysine residues in target proteins through an enzymatic cascade involving E1, E2, and E3 enzymes.
Primary ExpressionUbiquitous - High in brain, heart, liver
Molecular Weight11.6 kDa
Amino Acids101 aa
UniProt IDP63165
NCBI Gene ID7341
Ensembl IDENSG00000116030
OMIM601561
GeneCardsSUMO1
Human Protein AtlasSUMO1
Associated DiseasesALS
InteractionsSUMO2, RANBP2, UBIQUITIN, Sumo, AND, MFN1
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.38

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (12)

Ubiquitin
protein · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: associated_with
TFAM Gene
gene · KG edge: inhibits
SUMO2 — Small Ubiquitin-Like Modifier 2
gene · KG edge: interacts_with
SENP1 — SUMO Specific Peptidase 1
gene · KG edge: activates

Knowledge Graph (12 edges)

SUMO1 interacts_with SUMO2
SUMO1 interacts_with RANBP2
SUMO1 interacts_with UBIQUITIN
SUMO1 interacts_with Sumo
SUMO1 co_expressed_with SUMO2
SUMO1 interacts_with Ms
SUMO1 associated_with Als
SUMO1 associated_with ALS
SUMO1 interacts_with AND
SUMO1 participates_in ubiquitin-proteasome