gene 3,104 words KG: TEAD1 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:neuronal-survival
Contents

TEAD1 — TEA Domain Transcription Factor 1

🧬 Gene Info
Gene SymbolTEAD1
Full NameTEA Domain Transcription Factor 1
Chromosome11p15.4
Protein TypeTranscription Factor
Functionis a member of the TEA domain (TEA/ATTS) transcription factor family.
Amino Acids426 aa
Exons16
UniProt IDP28347
NCBI Gene ID7003
Ensembl IDENSG00000187091
OMIM189892
GeneCardsTEAD1
Human Protein AtlasTEAD1
Alternative NamesTEF-1, ETF, NTEF, TEAD
Protein ClassTranscription factor; Hippo pathway effector
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsPRDX3, YAP1, Rb, AND, Actin, Ras
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46
Glycine-Rich Domain Competitive Inhibition
Score: 0.43

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (11)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: activates
YAP1 — Yes-Associated Protein 1
gene · KG edge: activates
PRDX3 — Peroxiredoxin 3
gene · KG edge: activates
NF1 — Neurofibromin 1
gene · KG edge: therapeutic_target
IDH1 Gene - Isocitrate Dehydrogenase 1
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

TEAD1 regulates EGFR
TEAD1 therapeutic_target FGFR3
TEAD1 therapeutic_target NF1
TEAD1 therapeutic_target IDH1
TEAD1 activates PRDX3
TEAD1 activates YAP1
TEAD1 inhibits Rb
TEAD1 interacts_with YAP1
TEAD1 therapeutic_target GENES
TEAD1 therapeutic_target Tumor