gene 607 words KG: TLR3 2026-03-24
kind:genesection:genesstate:published
Contents

TLR3 — Toll-Like Receptor 3

🧬 Gene Info
Gene SymbolTLR3
Full NameToll-Like Receptor 3
Chromosome4q35
Protein TypeReceptor
FunctionTLR3 is expressed in microglia, astrocytes, neurons, and oligodendrocytes.
Primary Expressionvarious cell types in the brain and plays a critical role in antiviral immune responses and has been implicated in neurodegenerative diseases
Amino Acids904 aa
PathwaysNF-κB, MAPK pathway
UniProt IDQ9Y5Y9
NCBI Gene ID7098
Ensembl IDENSG00000164342
OMIM603029
GeneCardsTLR3
Human Protein AtlasTLR3
Associated DiseasesMs
InteractionsRIPK3, TLR1, TLR4, MYD88, TLR7, UBIQUITIN
KG Connections170 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: activates
CREB-independent Neuronal Survival Pathways
mechanism · KG edge: contributes_to
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

TLR3 regulates CXCL10
TLR3 expressed_in DISC1
TLR3 expressed_in RAGE
TLR3 expressed_in IRAK2
TLR3 expressed_in IL10
TLR3 expressed_in IRAK1
TLR3 expressed_in IKBKG
TLR3 expressed_in TLR2
TLR3 expressed_in TLR1
TLR3 expressed_in HMGB1