gene 503 words KG: TLR7 2026-03-24
kind:genesection:genesstate:published
Contents

TLR7 Gene

🧬 Gene Info
Gene SymbolTLR7
Full NameToll-Like Receptor 7
ChromosomeXp22.2
FunctionTLR7 is a type I transmembrane protein localized primarily in endosomal compartments:
Molecular Weight120 kDa
PathwaysNF-κB
UniProt IDQ9NYK5
NCBI Gene ID51284
Ensembl IDENSG00000196664
OMIM300365
GeneCardsTLR7
Human Protein AtlasTLR7
Extracellular domainLeucine-rich repeats (LRRs) for nucleic acid recognition
Transmembrane domainSingle pass membrane protein
TIR domainIntracellular signaling domain
Associated DiseasesInflammation, Ms
InteractionsCAT, ACTB, RAC2, CTSD, CDK4, CDKN1A
KG Connections121 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: regulates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: inhibits
MYD88 Gene
gene · KG edge: activates
MYC Gene
gene · KG edge: biomarker_for
MMP9 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TLR7 biomarker_for PPARGC1A
TLR7 biomarker_for MYC
TLR7 biomarker_for SLC11A1
TLR7 interacts_with CAT
TLR7 interacts_with ACTB
TLR7 interacts_with RAC2
TLR7 interacts_with CTSD
TLR7 interacts_with CDK4
TLR7 interacts_with CDKN1A
TLR7 interacts_with LCK