gene 528 words KG: UBR5 2026-03-24
kind:genesection:genesstate:published
Contents

UBR5 - Ubiquitin-Protein Ligase E3 Component N-Recognin 5

🧬 Gene Info
Gene SymbolUBR5
Full NameUbiquitin-Protein Ligase E3 Component N-Recognin 5
AliasesPage for UBR5
Chromosome8q22.3
Protein TypeLigase
FunctionUBR5 is a HECT-domain E3 ubiquitin ligase with multiple cellular functions:
Primary ExpressionUbiquitous, Brain (high), Testis
PathwaysChemoresistance, Circadian Rhythm, Ferroptosis, Proteasome, Ubiquitin-Proteasome
UniProt IDO95071
NCBI Gene ID51366
Ensembl IDENSG00000146233
GeneCardsUBR5
Human Protein AtlasUBR5
InteractionsPER2, CLOCK, BMAL1, UBIQUITIN, SLC7A11, TNF
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (13)

Ubiquitin
protein · KG edge: causes
Packard Center for ALS Research
institution · KG edge: therapeutic_target
SMAD3 — SMAD Family Member 3
gene · KG edge: regulates
SLC7A11 Gene - xCT Cystine/Glutamate Antiporter
gene · KG edge: inhibits
PER2 Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

UBR5 inhibits PER2
UBR5 inhibits CLOCK
UBR5 inhibits BMAL1
UBR5 inhibits UBIQUITIN
UBR5 therapeutic_target ATF3
UBR5 causes UBIQUITIN
UBR5 regulates CIRCADIAN RHYTHM
UBR5 regulates Proteasome
UBR5 regulates Ubiquitin-Proteasome
UBR5 regulates Circadian Rhythm