gene 962 words KG: WEE1 2026-03-26
kind:genesection:genesstate:published
Contents

WEE1 Gene

🧬 Gene Info
Gene SymbolWEE1
Full NameWEE1
Chromosome11p15.4
Protein TypeGene
Functionis a nuclear serine/threonine protein kinase that serves as the primary regulator of the G2/M cell cycle checkpoint in mammalian cells[@wee2021].
Subcellular LocalizationWEE1 localizes primarily to:
Molecular Weight70 kDa
Amino Acids646 aa
NCBI Gene IDSearch NCBI
GeneCardsWEE1
Human Protein AtlasWEE1
Associated Diseasesneurodegeneration
InteractionsSIRT1, DNA, DDIT3, FUS, CDK2, FOXO1
KG Connections38 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (4)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Fibroblast Growth Factor Signaling in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
VEGF (Vascular Endothelial Growth Factor)
gene · KG edge: therapeutic_target
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: therapeutic_target
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

WEE1 inhibits SIRT1
WEE1 therapeutic_target EGFR
WEE1 therapeutic_target VEGF
WEE1 therapeutic_target CANCER
WEE1 therapeutic_target Cancer
WEE1 inhibits Tumor
WEE1 activates DNA
WEE1 therapeutic_target KRAS
WEE1 therapeutic_target Colorectal Cancer
WEE1 therapeutic_target Tumor