protein 2,445 words KG: WEE1
Contents

WEE1 Protein (WEE1 Kinase)

🔬 Protein Info
Gene SymbolWEE1
Chromosome11p15.4
Protein TypeGene
Functionis a nuclear serine/threonine protein kinase that serves as the primary regulator of the G2/M cell cycle checkpoint in mammalian cells[@wee2021].
Subcellular Localization</strong></td><td>Nucleus</td></tr>
Molecular Weight70 kDa
Amino Acids646 aa
GeneCardsWEE1
Human Protein AtlasWEE1
Associated Diseasesneurodegeneration
InteractionsSIRT1, DNA, DDIT3, FUS, CDK2, FOXO1
KG Connections38 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Fibroblast Growth Factor Signaling in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
VEGF (Vascular Endothelial Growth Factor)
gene · KG edge: therapeutic_target
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: therapeutic_target
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

WEE1 inhibits SIRT1
WEE1 therapeutic_target EGFR
WEE1 therapeutic_target VEGF
WEE1 therapeutic_target CANCER
WEE1 therapeutic_target Cancer
WEE1 inhibits Tumor
WEE1 activates DNA
WEE1 therapeutic_target KRAS
WEE1 therapeutic_target Colorectal Cancer
WEE1 therapeutic_target Tumor