Contents

HCN2 Gene - Hyperpolarization-activated Cyclic Nucleotide-gated Channel 2

🧬 Gene Info

Gene Symbol	HCN2
Full Name	Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2
Chromosome	19q13.4
Function	HCN2 channels are voltage-gated cation channels that pass both Na+ and K+ currents with unusual gating properties.
Primary Expression	the sinoatrial (SA) node and atrioventricular (AV) node
Molecular Weight	95 kDa
UniProt ID	Q9P0R3
NCBI Gene ID	6138
Ensembl ID	ENSG00000145214
OMIM	616383
GeneCards	HCN2
Human Protein Atlas	HCN2
Pacemaker Current	Generates Ih, a depolarizing current activated by hyperpolarization
Resting Potential	Contributes to setting and stabilizing the resting membrane potential
Synaptic Integration	Modulates dendritic integration and synaptic plasticity
Associated Diseases	Absence Seizures, AD, Als, AMI, ARM
Interactions	AND, App, EPILEPSY, GENES, HCN, HCN1
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph