Contents

IFIH1 Gene (MDA5)

🧬 Gene Info

Gene Symbol	IFIH1
Protein Type	Receptor
Function	encodes a critical cytoplasmic RNA helicase that serves as a pattern recognition receptor for viral RNA.
Primary Expression	neurons, astrocytes, and microglia - Upregulated during viral infections - Elevated in neurodegenerative
Pathways	Interferon Signaling
Ensembl ID	ENSG00000165178
GeneCards	IFIH1
Human Protein Atlas	IFIH1
Ligand recognition	Long dsRNA (>1 kb), viral dsRNA genomes
Specificity	Picornaviruses, rotaviruses, noroviruses, some flaviviruses
Activation	Binding to viral RNA induces conformational changes
Oligomerization	Activated MDA5 forms filaments on dsRNA
Signaling	CARD domains interact with MAVS on mitochondria
Associated Diseases	neurodegeneration
Interactions	GNAI1, ATG16L1, GNG2, GNAI2, NOD2, GNAS
KG Connections	40 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph