Contents

KDM6A Gene

🧬 Gene Info

Gene Symbol	KDM6A
Full Name	KDM6A
Aliases	Lysine Specific Demethylase 6A (UTX), Lysine Specific Demethylase 6A (UTX
Protein Type	Epigenetic Regulator
Target Class	Epigenetic Regulator
Function	Small molecule inhibition of histone demethylase activity
Mechanism of Action	Small molecule inhibition of histone demethylase activity
Druggability	Low (0.35)
Clinical Stage	Phase I
Molecular Weight	160 kDa
Amino Acids	401 aa
Exons	29
Pathways	Epigenetic
UniProt ID	A0A087X0R0
NCBI Gene ID	Search NCBI
GeneCards	KDM6A
Human Protein Atlas	KDM6A
Associated Diseases	OXIDATIVE STRESS, SYNAPTIC PLASTICITY, cancer, inflammation, neurodegeneration
Known Drugs/Compounds	GSK-J4
Interactions	PI3K, GBM, MTOR, TP53, BRCA2, ATM
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	KDM6A-Mediated H3K27me3 Rejuvenation
KG Connections	153 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph