protein

BRCA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRCA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

166Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

BRCA2 is a protein involved in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Aging, Als, Anxiety. Connected to 117 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolBRCA2
Full NameBRCA2 DNA Repair Associated
Chromosome13q13.1
FunctionThe BRCA2 gene encodes BRCA2 DNA Repair Associated, involved in DNA repair and genomic stability
Molecular Weight384 kDa
PathwaysAutophagy, Ferroptosis, Homologous Recombination, Innate Immunity, Oxidative Stress
UniProt IDP51587
NCBI Gene ID675
Ensembl IDENSG00000139618
OMIM600185
GeneCardsBRCA2
Human Protein AtlasBRCA2
Associated DiseasesAls, Breast Cancer, Cancer, Carcinoma
InteractionsATM, HMGCR, BRCA1, PARP1, FERROPTOSIS, CANCER
KG Connections166 knowledge graph edges
DatabasesGeneCardsHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

BRCA2 Gene

gene · 654 words

dna-damage-repair

mechanism · 3555 words

FANCF Gene

gene · 2646 words

FANCC Gene

gene · 2477 words

fance

gene · 2416 words

DNA Damage Response in Alzheimer's Disease

mechanism · 2076 words

Pathway Diagram

graph TD
    BRCA2["BRCA2"] -->|"activates"| Carcinoma["Carcinoma"]
    BRCA2["BRCA2"] -->|"activates"| Ms["Ms"]
    BRCA2["BRCA2"] -->|"activates"| Tumor["Tumor"]
    BRCA2["BRCA2"] -->|"therapeutic target"| Aging["Aging"]
    BRCA2["BRCA2"] -->|"therapeutic target"| Ms_1["Ms"]
    BRCA2["BRCA2"] -->|"regulates"| Aging_2["Aging"]
    LC3["LC3"] -->|"activates"| BRCA2["BRCA2"]
    LC3B["LC3B"] -->|"activates"| BRCA2["BRCA2"]
    P62["P62"] -->|"activates"| BRCA2["BRCA2"]
    TRIM25["TRIM25"] -->|"activates"| BRCA2["BRCA2"]
    style BRCA2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (93)

TargetRelationTypeStr
Cancerassociated_withdisease1.00
CANCERassociated_withgene0.80
Carcinomaactivatesdisease0.75
Tumoractivatesdisease0.75
Alsexpressed_indisease0.75

Incoming (73)

SourceRelationTypeStr
BRCA1associated_withgene0.90
TP53associated_withgene0.70
CANCERassociated_withgene0.70
KRASassociated_withgene0.70
LC3activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found