Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BRCA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BRCA2 is a protein involved in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Aging, Als, Anxiety. Connected to 117 entities in the SciDEX knowledge graph.
| Gene Symbol | BRCA2 |
| Full Name | BRCA2 DNA Repair Associated |
| Chromosome | 13q13.1 |
| Function | The BRCA2 gene encodes BRCA2 DNA Repair Associated, involved in DNA repair and genomic stability |
| Molecular Weight | 384 kDa |
| Pathways | Autophagy, Ferroptosis, Homologous Recombination, Innate Immunity, Oxidative Stress |
| UniProt ID | P51587 |
| NCBI Gene ID | 675 |
| Ensembl ID | ENSG00000139618 |
| OMIM | 600185 |
| GeneCards | BRCA2 |
| Human Protein Atlas | BRCA2 |
| Associated Diseases | Als, Breast Cancer, Cancer, Carcinoma |
| Interactions | ATM, HMGCR, BRCA1, PARP1, FERROPTOSIS, CANCER |
| KG Connections | 166 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
BRCA2["BRCA2"] -->|"activates"| Carcinoma["Carcinoma"]
BRCA2["BRCA2"] -->|"activates"| Ms["Ms"]
BRCA2["BRCA2"] -->|"activates"| Tumor["Tumor"]
BRCA2["BRCA2"] -->|"therapeutic target"| Aging["Aging"]
BRCA2["BRCA2"] -->|"therapeutic target"| Ms_1["Ms"]
BRCA2["BRCA2"] -->|"regulates"| Aging_2["Aging"]
LC3["LC3"] -->|"activates"| BRCA2["BRCA2"]
LC3B["LC3B"] -->|"activates"| BRCA2["BRCA2"]
P62["P62"] -->|"activates"| BRCA2["BRCA2"]
TRIM25["TRIM25"] -->|"activates"| BRCA2["BRCA2"]
style BRCA2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 1.00 |
| CANCER | associated_with | gene | 0.80 |
| Carcinoma | activates | disease | 0.75 |
| Tumor | activates | disease | 0.75 |
| Als | expressed_in | disease | 0.75 |
| Breast Cancer | associated_with | disease | 0.75 |
| PARP1 | inhibits | gene | 0.70 |
| GENES | associated_with | gene | 0.70 |
| HMGCR | modifies | gene | 0.65 |
| Ms | activates | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Longevity | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Ataxia | regulates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Als | implicated_in | disease | 0.65 |
| Carcinoma | implicated_in | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Renal Cell Carcinoma | activates | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Prostate Cancer | treats | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Aging | treats | disease | 0.65 |
| Anxiety | expressed_in | disease | 0.65 |
| Depression | expressed_in | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Cancer | biomarker_for | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| FERROPTOSIS | inhibits | phenotype | 0.65 |
| FERROPTOSIS | modifies | phenotype | 0.65 |
| Homologous Recombination | activates | pathway | 0.60 |
| ATM | inhibits | gene | 0.60 |
| RANK | biomarker_for | gene | 0.60 |
| ATM | expressed_in | gene | 0.60 |
| RB1 | biomarker_for | gene | 0.60 |
| CDK12 | expressed_in | gene | 0.60 |
| AKT | biomarker_for | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| STK11 | associated_with | gene | 0.60 |
| BRIP1 | associated_with | gene | 0.60 |
| BRCA1 | associated_with | gene | 0.60 |
| PALB2 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BRCA1 | associated_with | gene | 0.90 |
| TP53 | associated_with | gene | 0.70 |
| CANCER | associated_with | gene | 0.70 |
| KRAS | associated_with | gene | 0.70 |
| LC3 | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| TRIM25 | activates | gene | 0.60 |
| CD38 | therapeutic_target | gene | 0.60 |
| FOXP1 | therapeutic_target | gene | 0.60 |
| TERT | therapeutic_target | gene | 0.60 |
| SIRT6 | regulates | gene | 0.60 |
| PARP1 | regulates | gene | 0.60 |
| HNRNPA1 | activates | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| DDX5 | activates | gene | 0.60 |
| PIN1 | regulates | gene | 0.60 |
| BRCA1 | regulates | gene | 0.60 |
| ATR | regulates | gene | 0.60 |
| HNRNPH1 | activates | gene | 0.60 |
| CDKN2A | associated_with | gene | 0.60 |
| MLH1 | associated_with | gene | 0.60 |
| PALB2 | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| ATM | regulates | gene | 0.60 |
| TP53 | regulates | gene | 0.60 |
| NBN | regulates | gene | 0.60 |
| BRIP1 | regulates | gene | 0.60 |
| STK11 | regulates | gene | 0.60 |
| CHEK2 | regulates | gene | 0.60 |
| PTEN | regulates | gene | 0.60 |
| PALB2 | regulates | gene | 0.60 |
| RAD51 | regulates | gene | 0.60 |
| NF1 | regulates | gene | 0.60 |
| KDM4A | associated_with | gene | 0.60 |
| FGFR3 | associated_with | gene | 0.60 |
| BICD2 | associated_with | gene | 0.60 |
| MITF | associated_with | gene | 0.60 |
| HSPA1A | associated_with | gene | 0.60 |
| PTEN | associated_with | gene | 0.60 |
| CDKN2A | activates | gene | 0.60 |
| BRCA1 | implicated_in | gene | 0.60 |
| PTEN | inhibits | gene | 0.60 |
| KDM6A | inhibits | gene | 0.60 |
| TP53 | inhibits | gene | 0.60 |
| BRCA1 | expressed_in | gene | 0.60 |
| CHEK2 | associated_with | gene | 0.60 |
| TP53 | expressed_in | gene | 0.60 |
| PTEN | expressed_in | gene | 0.60 |
| PI3K | biomarker_for | gene | 0.60 |
| BRCA1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||