| Gene Symbol | LPL |
| Full Name | Lipoprotein Lipase |
| Protein Type | Enzyme |
| Function | Lipoprotein Lipase (LPL) is a key enzyme in lipid metabolism that hydrolyzes triglycerides in circulating lipoproteins, primarily chylomicrons and very-low-density lipoproteins (VLDL). |
| Primary Expression | neurons (especially in hippocampus and cortex), astrocytes, and microglia - Regional Distribution: High expression i |
| Pathways | Cholesterol, Glycolysis, Immune Response, Lipid Metabolism, Oxidative Phosphorylation |
| GeneCards | LPL |
| Human Protein Atlas | LPL |
| Brain lipid homeostasis | Providing energy through fatty acid oxidation |
| Synaptic function | Supporting membrane lipid composition |
| Myelin maintenance | Delivering lipids for myelin sheath integrity |
| Neuroprotection | Modulating inflammation and oxidative stress [2] |
| Brain | LPL is expressed in neurons (especially in hippocampus and cortex), astrocytes, and microglia |
| Regional Distribution | High expression in the hippocampus, cerebral cortex, and basal ganglia |
| Upregulation | Induced during demyelination and in response to neuronal injury |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, Dementia, Diabetes |
| Interactions | ADRA2A, ALDH1A2, ALZHEIMER'S DISEASE, AMPK, APOE, AUTOPHAGY |
| KG Connections | 243 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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