Contents

GUSB Gene

🧬 Gene Info

Gene Symbol	GUSB
Chromosome	7q11.21
Protein Type	Hydrolase
Function	encodes a lysosomal hydrolase that catalyzes the hydrolysis of glucuronic acid residues from glycosaminoglycans (GAGs) within the lysosome.
Molecular Weight	73 kDa
Amino Acids	651 aa
Exons	11
Ensembl ID	ENSG00000135638
GeneCards	GUSB
Human Protein Atlas	GUSB
Human-Mouse	78% identical at the amino acid level
Human-Zebrafish	58% identical
Drosophila	Homolog with 35% identity
Yeast	Homologs in Saccharomyces cerevisiae (SGL1 and SGL2)
Heparan sulfate	Component of cell surfaces and extracellular matrix
Associated Diseases	Aging, Als, Cancer, Diabetes, Inflammation, Ms
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AMPK, CTSB, CTSD, EIF4EBP1, GFP
KG Connections	62 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph