protein

ALDH1A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALDH1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

169Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

Summary

ALDH1A1 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with Aging, Als, Cancer. Connected to 110 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ALDH1A1
Function	ALDH1A1 encodes aldehyde dehydrogenase 1A1, a cytosolic enzyme that catalyzes the oxidation of aldehydes to carboxylic acids.
Primary Expression	multiple brain regions: - Substantia nigra pars compacta - dopaminergic neurons (high expression) - Ventral tegmental area - dopaminergic neur
Pathways	Complement, Epigenetic, Ferroptosis, Metastasis, Notch
Ensembl ID	ENSG00000153208
GeneCards	ALDH1A1
Human Protein Atlas	ALDH1A1
Substantia nigra pars compacta	dopaminergic neurons (high expression)
Ventral tegmental area	dopaminergic neurons
Striatum	medium spiny neurons
Retina	retinal pigment epithelium
Liver	hepatocytes
Associated Diseases	Aging, Als, Diabetes, Ms
Interactions	EGFR, SLC18A2, SLC6A3, CANCER, FERROPTOSIS, PARKINSON
KG Connections	169 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ALDH1A1["ALDH1A1"] -->|"activates"| retinoic_acid_signaling["retinoic acid signaling"]
    ALDH1A1["ALDH1A1"] -->|"associated"| Diabetes["Diabetes"]
    ALDH1A1["ALDH1A1"] -->|"associated"| Als["Als"]
    ALDH1A1["ALDH1A1"] -->|"associated"| Aging["Aging"]
    ALDH1A1["ALDH1A1"] -->|"associated"| Ms["Ms"]
    ALDH1A1["ALDH1A1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    S100A9["S100A9"] -->|"activates"| ALDH1A1["ALDH1A1"]
    FGF21["FGF21"] -->|"associated"| ALDH1A1["ALDH1A1"]
    HMOX1["HMOX1"] -->|"associated"| ALDH1A1["ALDH1A1"]
    FGF20["FGF20"] -->|"therapeutic target"| ALDH1A1["ALDH1A1"]
    style ALDH1A1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (123)

Target	Relation	Type	Str
ferroptosis	regulates	process	0.90
Cancer	therapeutic_target	disease	0.75
retinoic acid signaling	activates	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Diabetes	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Lung Cancer	inhibits	disease	0.65
Als	causes	disease	0.65
Aging	causes	disease	0.65
Diabetes	causes	disease	0.65
Parkinson	inhibits	disease	0.65
Als	inhibits	disease	0.65
CTSD	associated_with	gene	0.60
LPL	therapeutic_target	gene	0.60
GUSB	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
HMOX1	associated_with	gene	0.60
MITF	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60

Incoming (46)

Source	Relation	Type	Str
UBIQUITIN	binds_to	protein	0.90
FBXL12	phosphorylates	protein	0.85
CD63	upregulates	gene	0.80
S100A9	activates	protein	0.70
FGF21	associated_with	gene	0.60
HMOX1	associated_with	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
CD44	therapeutic_target	gene	0.60
GUSB	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
LPL	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	targets	gene	0.60
CDH1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
BAMBI	therapeutic_target	gene	0.60
NEURON	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ALDH1A1

Understanding Entity Pages

Summary

Wiki Pages (21)

ALDH1A1 Gene

substantia-nigra

LEF1

Dopaminergic VTA Neurons in Parkinson's Disease

Cell Types

NURR1 Agonist Therapy for Parkinson's Disease

ALDH1A3 — Aldehyde Dehydrogenase 1 Family Member A3

Ventral Tegmental Area Glutamatergic Neurons

retinoic-acid-signaling-neurodegeneration

Substantia Nigra Pars Compacta Dopaminergic Neurons

EN2 Gene

EN1 Gene

Reward Prediction Error Cells

Substantia Nigra Dopaminergic Neurons

Astrocyte Iron Metabolism and Alpha-Synuclein Pathology in Parkinson's Disease

VTA Dopamine Neurons

Substantia Nigra Pars Compacta (SNc) Dopamine Neurons

iPSC-Derived Dopamine Neurons

Ventral Tegmental Area Dopamine Neurons