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Mechanism: Apoptosis Pathways in Alzheimer's Disease
mechanism
1,672 words
KG: apoptosis
Contents
Apoptosis Pathways in Alzheimer's Disease
⚙
Mechanism Info
Name
apoptosis
Key Genes/Proteins
ABCA7
,
ABCD3
,
ACTB
,
AIM2
,
Akt
,
AKT
Related Diseases
acetylcholine
,
aging
Linked Hypotheses
1 hypotheses
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Knowledge Graph
Related Hypotheses (30)
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Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
TREM2-mediated microglial tau clearance enhancement
Score: 0.80
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.75
LRP1-Dependent Tau Uptake Disruption
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
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VCP-Mediated Autophagy Enhancement
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Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
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Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
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Synaptic Vesicle Tau Capture Inhibition
Score: 0.64
Extracellular Vesicle Biogenesis Modulation
Score: 0.64
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.63
Vagal Afferent Microbial Signal Modulation
Score: 0.66
Vocal Cord Neuroplasticity Stimulation
Score: 0.72
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2-Dependent Microglial Senescence Transition
Score: 0.95
SASP-Mediated Complement Cascade Amplification
Score: 0.91
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
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Score: 0.89
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Transcriptional Autophagy-Lysosome Coupling
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Show 25 more
Related Analyses (30)
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Related Experiments (30)
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clinical · proposed · Score: 0.40
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clinical · proposed · Score: 0.40
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clinical · proposed · Score: 0.40
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Show 25 more
See Also (15)
ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Digital Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Dried Blood Spot Biomarker Test for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
DTI Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
EEG Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Eye-Tracking Digital Markers in Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Gait Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
GFAP in Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Inflammatory Biomarkers in Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Neurogranin - Alzheimer's Disease Biomarker
biomarker · Pages share 18 hypotheses
NPTX1 and NPTXR CSF Markers Predict Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Ocular Fluid Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Olfactory Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Plasma Phospho-Tau Ratio Diagnostic Panel for Alzheimer
biomarker · Pages share 18 hypotheses
Alzheimer's Disease Biomarkers
biomarker · Pages share 18 hypotheses
Show 10 more
Knowledge Graph (12 edges)
BDNF
inhibits
apoptosis
PI3K
inhibits
apoptosis
IL-6
enhances
apoptosis
bcl2a
enhances
apoptosis
HSPA1A
inhibits
apoptosis
HSPB1
inhibits
apoptosis
PIEZO1
regulates
apoptosis
endoplasmic_reticulum_stress
activates
apoptosis
oxidative_stress_response
activates
apoptosis
H2AX
activates
apoptosis
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