gene

HSPB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

323Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

HSPB1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 177 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HSPB1
Aliases	Hsp27
Chromosome	7q11.23.
Molecular Weight	27 kDa
Amino Acids	205 aa
Pathways	MAPK Pathway, NF-κB, PI3K
GeneCards	HSPB1
Human Protein Atlas	HSPB1
Associated Diseases	Aging, Als, Alzheimer, Cardiovascular, Ms, Multiple Sclerosis
Interactions	ALS, CH25H, ATF3, VIM, NEURODEGENERATION, CANCER
SciDEX Hypotheses	HSPB1 Phosphorylation Mimetics to Promote Protecti
KG Connections	323 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HSPB1["HSPB1"]
    HSPB1 -.protects against.-> neurodegeneration["neurodegeneration"]
    HSPB1 -->|"regulates"| poly_G_aggregates["poly-G aggregates"]
    HSPB1 -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    HSPB1 -->|"target for"| Alzheimer["Alzheimer"]
    HSPB1 -->|"regulates"| Ms["Ms"]
    HSPB1 -->|"target for"| Parkinson["Parkinson"]
    HSPB1 -->|"inhibits"| Cancer["Cancer"]
    HSPB1 -->|"inhibits"| Als["Als"]
    STAT3["STAT3"] -->|"regulates"| HSPB1
    CEBPA["CEBPA"] -->|"target for"| HSPB1
    HSPA1A["HSPA1A"] -->|"regulates"| HSPB1
    TFE3["TFE3"] -->|"target for"| HSPB1
    TP53["TP53"] -->|"target for"| HSPB1
    SPI1["SPI1"] -->|"target for"| HSPB1
    GENES["GENES"] -->|"regulates"| HSPB1
    CTSH["CTSH"] -->|"interacts"| HSPB1
    COMPLEMENT["COMPLEMENT"] -->|"interacts"| HSPB1

Outgoing (180)

Target	Relation	Type	Str
Apoptosis	inhibits	process	0.90
Alzheimer's Disease	upregulates	disease	0.85
Multiple Sclerosis	upregulates	disease	0.85
Parkinson's Disease	upregulates	disease	0.85
Apoptosis	suppresses	process	0.85
Inflammation	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Parkinson	expressed_in	disease	0.75
neurodegeneration	protects_against	process	0.70
poly-G aggregates	regulates	process	0.70
Multiple Sclerosis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	protects_against	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
apoptosis	inhibits	phenotype	0.64
TP53	therapeutic_target	gene	0.60
TFE3	therapeutic_target	gene	0.60
APOA2	associated_with	gene	0.60

Incoming (143)

Source	Relation	Type	Str
h-ff0d545d	targets_gene	hypothesis	0.90
SPI1	regulates	gene	0.80
CEBPA	regulates	gene	0.80
HSP90AA1	regulates	protein	0.80
STAT3	regulates	protein	0.70
INFLAMMATION	activates	gene	0.70
PARKINSON'S DISEASE	expressed_in	gene	0.70
NEURODEGENERATION	activates	gene	0.70
TP53	regulates	entity	0.70
CEBPA	therapeutic_target	gene	0.60
HSPA1A	regulates	gene	0.60
TFE3	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
SPI1	therapeutic_target	gene	0.60
HSPA1A	inhibits	gene	0.60
GENES	regulates	gene	0.60
STX4	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
CEBPA	associated_with	gene	0.60
CTSH	interacts_with	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
C1QB	interacts_with	gene	0.60
ASTROCYTES	activates	gene	0.60
SOD1	activates	gene	0.60
HSP27	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
APOA2	associated_with	gene	0.60
ANXA2	activates	gene	0.60
ICAM1	activates	gene	0.60
CD44	activates	gene	0.60
HMOX1	activates	gene	0.60
SPP1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
TIMP1	activates	gene	0.60
LGALS3	activates	gene	0.60
CD14	activates	gene	0.60
RGS1	activates	gene	0.60
ZFP36	activates	gene	0.60
ICAM1	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
SOCS3	associated_with	gene	0.60
IL6	associated_with	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
C5AR1	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43	0.598	neurodegeneration	What is the therapeutic window between i

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the therapeutic window between insufficient and toxic levels of TDP-43 a

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.615

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via [PMID:39936620]	Ding N, Song Y, Zhang Y, Yu W, Li X et a	Autophagy	2025
Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. [PMID:38507480]	Yang F, Beltran-Lobo P, Sung K, Goldrick	Sci Adv	2024
crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers tras [PMID:39243601]	Zou Y, Yang A, Chen B, Deng X, Xie J et	Drug Resist Updat	2024
HSPB1 facilitates chemoresistance through inhibiting ferroptotic cancer cell dea [PMID:37454220]	Liang Y, Wang Y, Zhang Y, Ye F, Luo D et	Cell Death Dis	2023
Integrating single-nucleus sequence profiling to reveal the transcriptional dyna [PMID:37735671]	Fan LY, Yang J, Liu RY, Kong Y, Guo GY e	J Transl Med	2023
Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Exp [PMID:35302338]	Ganassi M, Zammit PS	Eur J Transl Myol	2022
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liq [PMID:36075972]	Lu S, Hu J, Arogundade OA, Goginashvili	Nat Cell Biol	2022
Extracellular vesicle-associated small heat shock proteins as therapeutic agents [PMID:34673130]	Van den Broek B, Wuyts C, Irobi J	Adv Drug Deliv Rev	2021
Small heat shock proteins in neurodegenerative diseases. [PMID:32323160]	Vendredy L, Adriaenssens E, Timmerman V	Cell Stress Chaperones	2020
The small heat shock proteins, especially HspB4 and HspB5 are promising protecta [PMID:29425965]	Zhu Z, Reiser G	Neurochem Int	2018

HSPB1

Understanding Entity Pages

Summary

Wiki Pages (20)

Ferroptosis in Neurodegeneration

Heat Shock Protein Response Pathway in Neurodegeneration

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

MYT1L Gene

Protein Quality Control in Neurodegeneration

Charcot-Marie-Tooth Disease

Chaperone-Mediated Proteostasis Disease Comparison

HSPBAP1 — HSPB Associated Protein 1

Proteostasis Network in Neurodegeneration

Protein Aggregation in Neurodegeneration

CRYAB Gene

CEBPA Gene

Molecular Chaperones in Neurodegeneration

HSPB2 Gene (Heat Shock Protein Family B Member 2)

Protein Homeostasis in Neurodegeneration

Chaperone-Mediated Proteostasis in 4R-Tauopathies

Heat Shock Proteins

HSPB1 — Heat Shock Protein Family B Member 1

Protein Folding in Neurodegeneration