pathway 2,570 words KG: ferroptosis 2026-03-26
section:mechanismskind:pathwaytopic:alzheimerstopic:ferroptosistopic:irontopic:lipid-peroxidation
Contents

Ferroptosis Pathway in Alzheimer's Disease

🔀 Pathway Info
Nameferroptosis
SummaryComprehensive analysis of ferroptosis in Alzheimer's disease pathogenesis, including molecular mechanisms, iron dysregulation, lipid peroxidation, therapeutic targets, and clinical evidence
Key Genes/ProteinsSLC7A11, GPX4, sorcin, NRF2, STING, PCK2
Related Diseaseslipid_peroxidation, Ischemia/Reperfusion Injury, iron overload
Linked Hypotheses10 hypotheses

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40

See Also (15)

Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 19 hypotheses
Ubiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypotheses
Tau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Tau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 19 hypotheses

Knowledge Graph (12 edges)

ferroptosis contributes_to osteoarthritis
ferroptosis causes HSC
ferroptosis contributes_to diabetic_nephropathy
ferroptosis regulates lipid_peroxidation
ferroptosis regulates iron metabolism
ferroptosis regulates cysteine metabolism
ferroptosis causes neurodegeneration
ferroptosis causes myocardial ischemia-reperfusion injury
ferroptosis causes tumor cells
ferroptosis causes hemorrhagic transformation