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mechanism 1,059 words KG: PD 2026-04-01
mechanismmechanismspublished
Contents

Fibrinogen and αVβ3 Integrin in Alpha-Synuclein Pathology

⚙ Mechanism Info
NamePD
SummaryMechanism page: Fibrinogen binds to αVβ3 integrin on neurons and microglia, promoting alpha-synuclein aggregation and mitochondrial dysfunction in Parkinson's disease
Key Genes/ProteinsTP53, SNCA, LRRK2, GBA1, PRKN
Related DiseasesNEURODEGENERATION, NEUROINFLAMMATION, synucleinopathies, neurodegeneration
Linked Hypotheses3 hypotheses

Knowledge Graph

Related Hypotheses (15)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36Purinergic Signaling Polarization Control
Score: 0.55Mechanosensitive Ion Channel Reprogramming
Score: 0.51Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46Microbial Inflammasome Priming Prevention
Score: 0.58

Related Analyses (30)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (3)

RBG treatment in ApoE-/- atherosclerosis mouse model
validation · proposed · Score: 0.90Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (15)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: causesAge-Sensitive Cortical Vulnerability in Parkinson's Dis
mechanism · KG edge: associated_withMCL1 Gene - Myeloid Cell Leukemia 1
gene · KG edge: implicated_inIDH1 Gene - Isocitrate Dehydrogenase 1
gene · KG edge: implicated_ineef1a1
gene · KG edge: implicated_in

Knowledge Graph (12 edges)

PD causes NEURODEGENERATION
PD causes DOPAMINERGIC_NEURONS
PD causes neurodegeneration
PD contributes_to synucleinopathies
PD associated_with DEPRESSION
PD associated_with T2DM
NEUROINFLAMMATION contributes_to PD
NEUROTROPHINS treats PD
AGE associated_with PD
SNCA causes PD
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