Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AGE |
| Summary | Page for Life Biosciences |
| Key Genes/Proteins | AGER |
| Related Diseases | neurodegenerative diseases, ALS, AD, PD |
| Linked Hypotheses | 18 hypotheses |
Knowledge base pages for this entity
graph TD
AGE["AGE"]
AGE -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
AGE -->|"risk_factor_for"| Parkinson_s_Disease["Parkinson's Disease"]
AGE -->|"risk_factor_for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
AGE -->|"downregulates"| Microglial_Phagocytosis_of_Amy["Microglial Phagocytosis of Amyloid-beta"]
AGE -->|"upregulates"| Microglial_Phagocytosis_of_Syn["Microglial Phagocytosis of Synapses"]
AGE -->|"risk_factor_for"| Glaucoma["Glaucoma"]
AGE -->|"modulates"| Mature_Neuronal_Fate["Mature Neuronal Fate"]
AGE -->|"risk_factor_for"| Dementia["Dementia"]
PARKINSON["PARKINSON"] -->|"increases_risk"| AGE
autophagy["autophagy"] -->|"regulates"| AGE| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegenerative diseases | risk_factor | disease | 0.80 |
| ALS | associated_with | disease | 0.64 |
| AD | associated_with | disease | 0.64 |
| PD | associated_with | disease | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AGER | co_associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.544
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455
neurodegeneration | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.619
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213] | Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei | Neuron | 2026 | 0 |
| Role of TREM2 in neuroinflammation. [PMID:41213496] | Abdulkhaliq AA, Alasiri G, Almoghrabi Y, | Exp Neurol | 2026 | 0 |
| A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal [PMID:41365298] | Xu Y, Chen X, Fang R, Wang X, Zhang Y et | Immunity | 2026 | 0 |
| Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649] | Zhang J, St Pierre Schneider B, Muguerza | Am J Physiol Endocrinol Metab | 2026 | 0 |
| Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750] | Yang X, Zhao Y, Liu W, Feng J, Wu X et a | J Ethnopharmacol | 2026 | 0 |
| Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929] | Mateus-Tique J, Lakshmi A, Singh B, Iyer | Cancer Cell | 2026 | 0 |
| Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] | Li X, Tang X, Zeng J, Duan L, Hou Z et a | Cell | 2026 | 0 |
| TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393] | Feiten AF, Dahm K, Schlepckow K, van Len | Nat Commun | 2026 | 0 |
| Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant [PMID:41720086] | Zhao Q, Huang R, Wang C, Hu J, Nie R et | Cancer Cell | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876] | Chen F, Xue Y, Ma X, Chen L, Shao Z et a | Adv Sci (Weinh) | 2026 | 0 |
| Correction to "A Strategy Involving Microporous Microneedles Integrated with CAR [PMID:41952643] | Unknown | Advanced materials (Deerfield | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149] | Li C, Teng T, Lin X, Sun X, Yi T et al. | Cancer Res | 2026 | 0 |
| A cellular epigenetic classification system for glioblastoma. [PMID:41499453] | Silverbush D, Jürgensen L, Freeburg NF, | Neuro Oncol | 2026 | 0 |
| Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491] | Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan | J Gastroenterol Hepatol | 2026 | 0 |
| P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526] | Yan L, Zheng J, Lu Z, Zhu A, Ye M et al. | Circulation | 2026 | 0 |
| Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834] | Ye D, Zhou H, Qu S, Wang Z, Zhang F et a | Cell Death Discov | 2026 | 0 |