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mechanism 1,525 words KG: MAPT 2026-04-01
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

Pick Bodies

⚙ Mechanism Info
NamePick Bodies
SummaryPage for Pick Bodies
Key Genes/ProteinsTAU, 0N3R, NEURODEGENERATION, DEMENTIA, ALZHEIMER'S DISEASE, MICROTUBULE-ASSOCIATED PROTEIN TAU

Knowledge Graph

Related Hypotheses (6)

Glymphatic-Mediated Tau Clearance Dysfunction
Score: 0.55Dual-Circuit Tau Vulnerability Cascade
Score: 0.50Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio
Score: 0.49Transcriptional Autophagy-Lysosome Coupling
Score: 0.66Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (30)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSleep disruption as cause and consequence of neurodegenerati
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (3)

Tau depletion effects on neuronal development in primary cul
exploratory · proposed · Score: 0.90Microtubule domain analysis in adult axons
exploratory · proposed · Score: 0.80Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

MAPT encodes TAU
MAPT associated_with MAP6
MAPT interacts_with PARP1
MAPT interacts_with PEN2
MAPT interacts_with PSEN1
MAPT interacts_with DAPK1
MAPT interacts_with HSPG2
MAPT interacts_with IL1B
MAPT activates APP
MAPT interacts_with EIF2AK2
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