pathway 2,633 words KG: ent-gene-1f51bfd1 2026-04-01
section:mechanismskind:pathwaytopic:parkinsonstopic:mitochondria
Contents

PINK1-Parkin Mitophagy Complex

🔬 Protein Info
Gene SymbolPINK1
Full NameParkin Mitophagy Complex
Chromosome1p36.12
Protein FamilySerine/threonine kinase family
Protein TypeKinase
Functionis a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary ExpressionMitochondrial outer membrane
Subcellular Localizationmitochondria[@narendra2008]:
Molecular Weight63 kDa
PathwaysAmyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt IDQ9BXM7
NCBI Gene ID65018
Ensembl IDENSG00000158828
OMIM608309
GeneCardsPINK1
Human Protein AtlasPINK1
Associated DiseasesAD, ALI, ALS, APOPTOSIS, Aging
Known Drugs/CompoundsDEFERIPRONE, RAPAMYCIN, MELATONIN, THSG, Gastrodin, icaritin
InteractionsBCL2L13, NLRP3, ABCD3, FIP200, RTN3, SESN2
KG Connections3652 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.38
APOE-Dependent Autophagy Restoration
Score: 0.63
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.42

Related Analyses (30)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (14)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-1f51bfd1 data_in benchmark_ot_ad_answer_key:PINK1
benchmark_ot_ad_answer_key:PINK1 data_in ent-gene-1f51bfd1