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mechanism 2,529 words KG: proteostasis
Contents

Proteostasis Network in Neurodegeneration

⚙ Mechanism Info
Nameproteostasis
Key Genes/ProteinsASTROCYTE, ATF4, C9ORF72, CTSD, deubiquitinating enzymes, DNAJB6
Related Pathwaysautophagy, autophagy-lysosome pathway, GLP-1 signaling, heat-shock response
Linked Hypotheses11 hypotheses

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Related Hypotheses (150)

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Score: 0.95
← Prevpg 7/8Next →

Related Analyses (30)

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neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
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falsification · proposed · Score: 0.40Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
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clinical · proposed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (12 edges)

protein quality control regulates proteostasis
proteostasis protects_against pathological conditions
C9ORF72 regulates proteostasis
TDP-43 regulates proteostasis
DNAJB6 involved_in proteostasis
TFEB promotes proteostasis
deubiquitinating enzymes regulates proteostasis
RAB7A hyperactivation associated_with proteostasis
HSP90 regulates proteostasis
Hsp110 regulates proteostasis

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