mechanism 1,285 words KG: ent-gene-257405c9 2026-03-24
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease

🔬 Protein Info
Gene SymbolSTING
Full NameCASM-GABARAP-LRRK2 Pathway in Parkinson's Disease
AliasesTMEM173
Chromosome5q31.2
Functionis a transmembrane protein that serves as the central signaling hub for the cGAS-STING pathway, one of the most important innate immune sensing mechanisms in eukaryotic cells.
Molecular Weight42 kDa
Amino Acids379 aa
Exons6
PathwaysNF-κB
UniProt IDQ86WV1
NCBI Gene ID340061
Ensembl IDENSG00000184584
OMIM612374
GeneCardsSTING
Human Protein AtlasSTING
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/CompoundsMELATONIN, curcumin, resveratrol, quercetin, dimethyl fumarate, DEXAMETHASONE
InteractionsPARP1, IRF3, CD68, TBK1, GPX4, CGAS
KG Connections2990 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (17)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.51
Noradrenergic-Tau Propagation Blockade
Score: 0.51

Related Analyses (30)

What determines the specificity of TDP-43-induced mitochondr
neurodegeneration · failed
How does chronic cGAS/STING activation downstream of TDP-43
neuroinflammation · failed
What upstream mechanisms cause TDP-43 to trigger mPTP openin
neurodegeneration · failed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95
TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90
TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90
cGAMP biomarker analysis in ALS patient spinal cord samples
clinical · proposed · Score: 0.85

Knowledge Graph (2 edges)

ent-gene-257405c9 data_in benchmark_ot_ad_answer_key:STING
benchmark_ot_ad_answer_key:STING data_in ent-gene-257405c9