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mechanism 706 words KG: AD
Contents

mitochondrial-dysfunction-ad

⚙ Mechanism Info
NameAD
Key Genes/ProteinsA2M, AB, ABCA1, ABCB1, ABCD3, ABCG1
Related DiseasesAGE
Linked Hypotheses127 hypotheses

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Related Hypotheses (143)

Closed-loop optogenetic targeting PV interneurons to restore
Score: 0.96Closed-loop tACS targeting EC-II parvalbumin interneurons to
Score: 0.87Closed-loop focused ultrasound targeting EC-II PV interneuro
Score: 0.86TDP-43 RNA-proteostasis failure across ALS, FTD, and AD/LATE
Score: 0.83Real-time gamma-guided transcranial focused ultrasound targe
Score: 0.83MAPT tau seeding and release across AD, FTD, and PD-spectrum
Score: 0.81Neutrophil Extracellular Trap (NET) Inhibition
Score: 0.81TREM2-APOE microglial state switching across AD, ALS, and PD
Score: 0.80CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind
Score: 0.80NLRP3 inflammasome amplification across AD and PD proteinopa
Score: 0.80PINK1/Parkin mitophagy failure across PD, AD, and ALS
Score: 0.80NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A
Score: 0.79Closed-loop tACS targeting EC-II PV interneurons to suppress
Score: 0.79PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifie
Score: 0.78ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v
Score: 0.77H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from E
Score: 0.77PARP1-NAD+-AIF bioenergetic collapse drives a self-amplifyin
Score: 0.76Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanis
Score: 0.76Night-phase orexin receptor antagonism rescues AD by restori
Score: 0.76GRN/progranulin lysosomal insufficiency across FTD, ALS-spec
Score: 0.76
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Knowledge Graph (12 edges)

GSS implicated_in AD
CYP2E1 implicated_in AD
IDH2 implicated_in AD
IDH1 implicated_in AD
VEGFA implicated_in AD
EEF1A1 implicated_in AD
APOB implicated_in AD
MET implicated_in AD
MCL1 implicated_in AD
SF3B1 implicated_in AD

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