| Gene Symbol | PDGFRA |
| Full Name | Platelet-Derived Growth Factor Receptor Alpha |
| Aliases | Page for PDGFRA |
| Chromosome | 4q12 |
| Protein Type | Gene |
| Function | PDGFRA signaling regulates cell proliferation, migration, and survival during development and tissue repair [@uniprot]: |
| Primary Expression | mesenchymal cells including fibroblasts, smooth muscle cells, and glial progenitors [@references] |
| Molecular Weight | 180 kDa |
| Amino Acids | 1086 aa |
| Exons | 23 |
| Pathways | Akt, Differentiation, MAPK signaling, ubiquitin-proteasome |
| GeneCards | PDGFRA |
| Human Protein Atlas | PDGFRA |
| Extracellular domain | Five immunoglobulin-like (Ig) domains that mediate ligand binding and receptor dimerization |
| Transmembrane domain | Single pass alpha-helical transmembrane region |
| Associated Diseases | ALS, Cancer, Carcinoma, Glioma, OPC maturation arrest, Tumor |
| Interactions | AKT, AKT3, App, CANCER, CDKN2A, EPHA2 |
| SciDEX Hypotheses | OPC Maturation Block via PDGFRA/LXRβ OPC differentiation blockade contributes to white Oligodendrocyte Precursor Cell Activation for Remy |
| KG Connections | 104 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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