gene

EPHA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

0Analyses

48Outgoing

15Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	EPHA2
Full Name	Eph Receptor A2
Chromosome	1p34.3
Protein Type	Receptor
Function	is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication.
Primary Expression	the dentate gyrus, where it plays a critical role in adult neurogenesis
Amino Acids	976 aa
Exons	17
Pathways	focal adhesion
UniProt ID	P21802
NCBI Gene ID	1969
Ensembl ID	ENSG00000142627
OMIM	176945
GeneCards	EPHA2
Human Protein Atlas	EPHA2
Associated Diseases	Thymic Epithelial Tumors
Interactions	GBM, PDGFA, FLOT1, P38, TAU, APP
KG Connections	63 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPHA2 — AlphaFold P21802 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EPHA2["<b>EPHA2</b>"]
    Ms{"Ms"}
    EPHA2 -->|"interacts with"| Ms
    Glioblastoma{"Glioblastoma"}
    EPHA2 -->|"therapeutic target"| Glioblastoma
    GBM["GBM"]
    EPHA2 -->|"inhibits"| GBM
    PDGFA["PDGFA"]
    EPHA2 -->|"inhibits"| PDGFA
    Akt(["Akt"])
    EPHA2 -->|"activates"| Akt
    neurodegeneration["neurodegeneration"]
    EPHA2 -->|"implicated in"| neurodegeneration
    PDGFRA["PDGFRA"]
    PDGFRA -->|"inhibits"| EPHA2
    AKT["AKT"]
    AKT -->|"activates"| EPHA2
    style EPHA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (48)

Target	Relation	Type	Str
P38/Mapk Signaling	activates	pathway	0.95
AKT	upstream_of	protein	0.90
Microglial Polarization	regulates	process	0.90
Thymic Epithelial Tumors	associated_with	disease	0.80
focal adhesion	regulates	pathway	0.75
Ms	interacts_with	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
GBM	inhibits	gene	0.60
PDGFA	inhibits	gene	0.60
APP	activates	gene	0.60
Rb	activates	protein	0.60
Akt	activates	pathway	0.60
AMYLOID-BETA	activates	gene	0.60
APP/PS1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Mapk	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
FOSL2	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
TAU TANGLES	activates	gene	0.60
Neuroinflammatory	activates	pathway	0.60
Amyloid	activates	pathway	0.60
Aβ	activates	protein	0.60
Cytokine	activates	protein	0.60
Amyloid-Beta	activates	protein	0.60
Ras	interacts_with	protein	0.60
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
FLOT1	activates	gene	0.50
P38	activates	protein	0.50
TAU	activates	protein	0.50
FLOT1	interacts_with	gene	0.50
MAPK	activates	gene	0.50
NEURON	co_discussed	gene	0.50
WAS	activates	protein	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
CHIP	interacts_with	protein	0.50
MAPK SIGNALING	activates	concept	0.50

Incoming (16)

Source	Relation	Type	Str
CLDN1	interacts_with	protein	0.95
FLOT1	regulates	gene	0.95
FOSL2	upregulates	gene	0.95
CLDN1	inhibits	protein	0.90
PDGFRA	inhibits	gene	0.60
AKT	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
FOSL2	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
CHIP	activates	protein	0.50
Neuroinflammation	activates	process	0.50
microglia	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EPHA2

Understanding Entity Pages

Wiki Pages (21)

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Ephrin/Eph Signaling Pathway in Neurodegeneration

EPHB6 — Ephrin Type-B Receptor 6