protein 1,489 words KG: CACNA1CPROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Cav1.2 Protein (L-type Calcium Channel Alpha-1C)

🔬 Protein Info
Gene SymbolCACNA1C
AliasesPage for Cav1.2
FunctionCACNA1C encodes the alpha-1C subunit of the L-type voltage-gated calcium channel (Cav1.2), one of the most important calcium channels in neurons and cardiac myocytes
Primary Expressionthe brain, heart, and smooth muscle
Subcellular LocalizationSomatodendritic compartment, dendritic spines, cardiac cells
Molecular Weight250 kDa
PathwaysWnt signaling, oxidative stress response
UniProt IDQ13936
GeneCardsCACNA1C
Human Protein AtlasCACNA1C
SubunitGene
α1CCACNA1C
β1-4CACNB1-4
α2δ1-4CACNA2D1-4
γ1-8CACNG1-8
Associated DiseasesAlzheimer, Anxiety, Cancer, Inflammation, Ms, psychiatric disorders
InteractionsCACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I
KG Connections225 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49

Related Analyses (12)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40
Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in