protein 752 words KG: CASS4 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

CASS4 Protein

🔬 Protein Info
Gene SymbolCASS4
Protein FamilyCAS family (CT10 Regulated Inositol Polyphosphate 4-phosphatase Type I)
Protein TypeScaffold Protein
FunctionCASS4 participates in cellular processes
Primary Expressionneurons and immune cells
Subcellular LocalizationCytoplasm, plasma membrane
Molecular Weight49 kDa
Amino Acids442 aa
PathwaysPI3K
UniProt IDQ9H6S3
GeneCardsCASS4
Human Protein AtlasCASS4
Protein NameCASS4
GeneCASS4
ApproachStrategy
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Autoimmune, Cancer
InteractionsEPHA1, CLU, BIN1, CD33, CD2AP, APOE
KG Connections155 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (7)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates
CASS2 — CASP2 and RIPK1 Domain Containing Adaptor
gene · KG edge: interacts_with
BIN1 — Bridging Integrator 1
gene · KG edge: activates

Knowledge Graph (12 edges)

CASS4 provides_data_for ds-83b31ef18d49
CASS4 associated_with CD33
CASS4 associated_with NME8
CASS4 associated_with BIN1
CASS4 associated_with CD2AP
CASS4 associated_with INPP5D
CASS4 associated_with EPHA1
CASS4 associated_with CLU
CASS4 associated_with CELF1
CASS4 associated_with MEF2C