| Gene Symbol | CHEK2 |
| Aliases | Checkpoint Kinase 2 |
| Chromosome | 22q12.1 |
| Protein Family | Serine/Threonine protein kinase (CMGC family) |
| Protein Type | Serine/Threonine Kinase |
| Function | is a serine/threonine kinase that plays a central role in the cellular response to DNA damage. |
| Primary Expression | Nucleus, cytoplasm |
| Subcellular Localization | Nucleus, cytoplasm |
| Molecular Weight | 60 kDa (543 amino acids) |
| Amino Acids | 543 aa |
| Exons | 14 |
| Pathways | cascade:
```mermaid |
| UniProt ID | O96017 |
| GeneCards | CHEK2 |
| Human Protein Atlas | CHEK2 |
| Associated Diseases | Breast Cancer, Cancer, NEURODEGENERATION |
| Interactions | TP53 |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |